1,2,4-Oxadiazole, 5-(chloromethyl)-3-(1,1-dimethylethyl)- - Names and Identifiers
Name | 3-(tert-Butyl)-5-(chloromethyl)-1,2,4-oxadiazole
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Synonyms | 3-TERT-BUTYL-5-(CHLOROMETHYL)-1,2,4-OXADIAZOLE 3-(tert-Butyl)-5-(chloromethyl)-1,2,4-oxadiazole 1,2,4-Oxadiazole, 5-(chloromethyl)-3-(1,1-dimethylethyl)-
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CAS | 944901-64-8
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1,2,4-Oxadiazole, 5-(chloromethyl)-3-(1,1-dimethylethyl)- - Physico-chemical Properties
Molecular Formula | C7H11ClN2O
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Molar Mass | 174.63 |
Storage Condition | Room Temprature |
Sensitive | Irritant |
MDL | MFCD09738869 |
1,2,4-Oxadiazole, 5-(chloromethyl)-3-(1,1-dimethylethyl)- - Risk and Safety
1,2,4-Oxadiazole, 5-(chloromethyl)-3-(1,1-dimethylethyl)- - Introduction
3-(tert-Butyl)-5-(chloromethyl)-1,2,4-oxadiazole is an organic compound. Its chemical formula is C9H14ClN3O, and its structure contains a 1,2, 4-oxadiazole ring and a chloromethyl group. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless to slightly yellow crystal
-Melting point: 62-64 degrees Celsius
-Boiling point: 284 degrees Celsius
-Density: 1.23g/cm³
-Solubility: Soluble in methanol, acetone and carbon disulfide, almost insoluble in water
Use:
- 3-(tert-Butyl)-5-(chloromethyl)-1,2,4-oxadiazole is often used in organic synthesis reactions as an important intermediate.
-It can be used to synthesize other oxygen-containing heterocyclic compounds, such as oxygen-containing heterocyclic stress antibiotics and fungicides, and has important potential for drug and pesticide applications.
Preparation Method:
The preparation method of 3-(tert-Butyl)-5-(chloromethyl)-1,2,4-oxadiazole can be carried out by the following steps:
1. reacting tert-butylglycine with 1,2-dibromoethane to synthesize substituted urea compounds;
2. The substituted urea compound reacts with chloromethyl ketone under alkaline conditions to generate 3-(tert-Butyl)-5-(chloromethyl)-1,2,4-oxadiazole.
Safety Information:
-The compound is generally stable and operable under normal laboratory conditions.
-However, due to the chloromethyl group, it may be irritating to the skin, eyes and respiratory system. Therefore, appropriate personal protective equipment should be worn during operation to avoid direct contact. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help if necessary.
-Avoid contact with strong oxidants and high temperature sources during storage and handling to prevent fire and explosion risks.
Please note that for the safe and correct use of chemicals, please read and follow the relevant safety operating guidelines and laboratory operating procedures before performing any experiments or applications.
Last Update:2024-04-09 21:04:16